A Clinical Randomized Trial on Endocervical Inflammatory Cytokines and Betamethasone in Prime-Gravid Pregnant Women at Risk of Preterm Labor
نویسندگان
چکیده مقاله:
Background: There are strong evidences suggesting the secretion of different cytokines in cervical fluid during preterm labor. Betamethasone is widely administered for several reasons in preterm conditions. Objective: To Investigate the possible effect of betamethasone on endocervical cytokine concentration of women at risk of preterm labor. Methods: In a randomized clinical trial of 80 prime-gravid women in preterm labor between 34 and 37 weeks of gestation, cervical fluid was collected. Endocervical concentration of inflammatory cytokines were analyzed before and 48 hours after betamethasone treatment for the evaluation of IL-8, IL-17, IFN-γ and TGF-β. Wilcoxon and Mann-Whitney tests were employed for statistical analysis. χ2 and Student’s t tests were used whenever needed. Results: All the measured cytokines showed significant changes in the betamethasone treated group. IL-17 (p=0.001), IL-8 (p=0.001), and IFN- γ (p
منابع مشابه
a clinical randomized trial on endocervical inflammatory cytokines and betamethasone in prime-gravid pregnant women at risk of preterm labor
background: there are strong evidences suggesting the secretion of different cytokines in cervical fluid during preterm labor. betamethasone is widely administered for several reasons in preterm conditions. objective: to investigate the possible effect of betamethasone on endocervical cytokine concentration of women at risk of preterm labor. methods: in a randomized clinical trial of 80 prime-g...
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عنوان ژورنال
دوره 9 شماره 3
صفحات 199- 207
تاریخ انتشار 2012-09-01
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